Gout
- Adult men or women ≥18 years of age
- Failure to maintain normalization of serum uric acid level on uric acid lowering medications
- Must have current flares defined as 2 or more flares in the past 12 months prior to screening
- Cannot exceed more than 3 alcoholic beverages weekly
- No prior treatment with pegloticase (Krystexxa) or Methotrexate
- Cannot have current diagnosis of chronic kidney disease or congestive heart failure